503 Use of low-dose spironolactone in female pattern hair loss in a specialty alopecia clinic
نویسندگان
چکیده
Female pattern hair loss (FPHL) results from a combination of hormones, aging, and genetics, is the most common type alopecia in women. Topical minoxidil remains only US Food Drug Administration (FDA)-approved treatment for this condition, although numerous other therapies have demonstrated efficacy recent years. Spironolactone, weak androgen receptor inhibitor, largely effective at various doses, but evidence on its use FPHL limited. A retrospective chart review was conducted adult women specialty clinic with treated low-dose spironolactone, defined as ≤50mg daily, either monotherapy or therapy therapeutic agents. We identified 14 patients seen within two-year span spironolactone. The average age 59 years ranged 46 to 79. Amongst all patients, 11 (78.6%) Caucasian, 1 (7.1%) Asian, Black Hispanic. Spironolactone dose 25mg 50mg, 46.4mg. About 50% were medications, namely topical 5% foam and/or low-level light laser least 6 months before starting Sinclair scale spironolactone 2.64, which decreased 2.11 approximately 1-year after Reported adverse events included breast tenderness patient, dizziness 2 one self-resolved, nausea patient increased urination patient. These side effects mild did not lead discontinuation medication any patients. Hyperkalemia observed an change Low-dose may be effective, well-tolerated female loss, especially beneficial who are unable endure higher doses. Further large-scale studies warranted better understand efficacy.
منابع مشابه
Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone.
BACKGROUND Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. OBJECTIVE To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. METHODS Women newly diagnosed with a Sinclair stage 2-5 PHL were scored for hair shedding and hair density before and after 12 months of treatment with...
متن کاملFemale Pattern Hair Loss
CONTEXT Female pattern hair loss (FPHL) also known as female androgenetic alopecia is a common condition afflicting millions of women that can be cosmetically disrupting. Prompt diagnosis and treatment are essential for obtaining optimal outcome. This review addresses the clinical presentation of female pattern hair loss, its differential diagnosis and treatment modalities. EVIDENCE ACQUISITI...
متن کاملfemale pattern hair loss
results: the most important diseases to consider in the differential diagnosis of fphl include chronic telogen effluvium (cte), permanent alopecia after chemotherapy (pac), alopecia areata incognito (aai) and frontal fibrosing alopecia (ffa). this review describes criteria for distinguishing these conditions from fphl. conclusions: the only approved treatment for fphl, which is 2% topical minox...
متن کاملHormonal therapy in female pattern hair loss
Female pattern hair loss is the most common cause of hair loss in women and one of the most common problems seen by dermatologists. This hair loss is a nonscarring alopecia in which loss occurs on the vertex scalp, generally sparing the frontal hairline. Hair loss can have significant psychosocial effects on patients, and treatment can be long and difficult. The influence of hormones on the pat...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.509